"Oh My Geum-bi" is a heartwarming family drama that follows the life of a sweet and adorable, yet strong-willed ten-year-old girl, Yoo Geum-bi (Heo Jung-eun). She suffers from a rare genetic disease called Niemann-Pick Disease Type C that makes her body unable to properly metabolize cholesterol and other lipids. It's a condition commonly referred to as "children's Alzheimer's" because of the rapid mental and physical deterioration symptoms that it causes.
As if life is not tough enough on Geum-bi already, after thinking her mom has passed away, she gets abandoned by the only aunt she knows, and is forced to track down her only remaining relative - her estranged conman father, Mo Hwi-cheol (Oh Ji-ho). As a swindler living a purposeless life, Hwi-cheol is shocked to hear about Geum-bi's existence and immediately wants nothing to do with her. And just like that, we're introduced to an onslaught of characters, all unique and important in their own ways.
While Hwi-cheol and his two friends attempt to con Go Kang-hee (Park Jin-hee), a pessimistic arborist who's trying to sell her father's ceramics, Geum-bi gets in the way of their plans. However, as Hwi-cheol is behind on rent, they eventually end up living with Kang-hee, who treats Geum-bi as her own daughter and completes the full picture of a "fake family".
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